Caracterización de DELUX: Dispositivo de esterilización por luz ultravioleta para máscaras PFF2/N95 contra COVID-19

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Resumen

La Organización Mundial de la Salud (OMS) declaró un estado pandémico de salud pública debido a transmisión del nuevo coronavirus el 11 de marzo de 2020. La COVID-19, causada por el SARS-CoV-2, tiene un espectro clínico muy amplio, con predominio de desarrollos sintomáticos respiratorios. El papel de los profesionales de salud en la lucha contra la pandemia requiere un equipo de protección personal (EPP). Las máscaras PFF2 / N95 son EPP adecuados para este propósito. Debido a gran demanda de máscaras PFF2 / N95 para combatir la pandemia, hubo escasez en el mercado. Este trabajo tiene como objetivo caracterizar un dispositivo denominado DELUX para la esterilización por UVC (espectros de luz ultravioleta C) de mascarillas PFF2 / N95, ampliando su tiempo de uso seguro en condiciones de emergencia. La validación fotométrica del dispositivo permitió la verificación del espectro de emisión de las lámparas empleadas en el dispositivo y la medición de la potencia óptica, demostrando la idoneidad de la irradiación con luz UVC, en ciclos de 15 minutos, de forma segura. La validación biológica mostró que DELUX es capaz de desactivar el SARS-CoV-2 presente en la superficie de las mascarillas PFF2 / N95, siendo así eficiente para su esterilización extendiendo el tiempo de utilización de estas mascarillas.

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Número Especial: Uso de técnicas de ingeniería para combatir COVID-19

Referencias

[1] S. Payne, “Family coronaviridae,” Elsevier Public Health Emergency Collection, pp. 149–158, 2017. [Online]. Available: https://dx.doi.org/10.1016/B978-0-12-803109-4.00017-9
[2] J. S. M. Peiris, “Coronaviruses,” Elsevier Public Health Emergency Collection, pp. 587–593. [Online]. Available: https://dx.doi.org/10.1016/B978-0-7020-4089-4.00072-X
[3] M. D. S. Cespedes and J. C. R. P. Souza, “Sars-cov-2: A clinical update - ii,” Revista da Associação Médica Brasileira, vol. 66, no. 4, pp. 547–557. [Online]. Available: https://doi.org/10.1590/1806-9282.66.4.547
[4] M. Pal, G. Berhanu, C. Desalegn, and V. Kandi, “Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Update,” Pal M, Berhanu G, Desalegn C, Kandi V. Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2): An Update. Cureus. 2020;12(3):e7423. Published 2020 Mar 26. doi:10.7759/cureus.7423, vol. 12, no. 3, p. e7423, 2020. [Online]. Available: https://dx.doi.org/10.7759/cureus.7423
[5] D. X. Liu, J. Q. Liang, and T. S. Fung, “Human coronavirus-229e, -oc43, -nl63, and -hku1 (coronaviridae),” Elsevier Public Health Emergency Collection, pp. 428–440. [Online]. Available: https://dx.doi.org/10.1016/B978-0-12-809633-8.21501-X
[6] M. Wang, R. Cao, L. Zhang, X. Yang, J. Liu, M. Xu, Z. Shi, Z. Hu, W. Zhong, and G. Xiao, “Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro,” Cell research, vol. 30, no. 3, pp. 269–271, 2020. [Online]. Available: https://doi.org/10.34172/jrcm.2020.005
[7] S. H. Alfaraj, J. A. Al-Tawfiq, A. Y. Assiri, N. A. Alzahrani, A. A. Alanazi, and Z. A. Memish, “Clinical predictors of mortality of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection: A cohort study,” Travel Medicine and Infectious Disease, vol. 29, pp. 48–50. [Online]. Available: https://doi.org/10.1016/j.tmaid.2019.03.004
[8] L. Piroth, J. Cottenet, A.-S. Mariet, P. Bonniaud, M. Blot, P. Tubert-Bitter, and C. Quantin, “Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study,” The Lancet Respiratory Medicine, vol. 9, no. 3, pp. 251–259, 2021. [Online]. Available: https://doi.org/10.1016/S2213-2600(20)30527-0
[9] FIOCRUZ. (2021) Por que a doença causada pelo novo coronavírus recebeu o nome de Covid-19? Fundação Oswaldo Cruz. [Online]. Available: https://bit.ly/3pwoiEE
[10] J. Zhang, W. Wu, X. Zhao, and W. Zhang, “Recommended psychological crisis intervention response to the 2019 novel coronavirus pneumonia outbreak in China: a model of West China Hospital,” Precision Clinical Medicine, vol. 3, no. 1, pp. 3–8, 02 2020. [Online]. Available: https://doi.org/10.1093/pcmedi/pbaa006
[11] M. Relvas, J. C. ao, R. Oliveira, J. C. Cardoso, and M. Gonçalo, “Manifestações cutaneas associadas a COVID-19: Uma revisão narrativa,” Revista Científica da Ordem dos Médicos, vol. 34, no. 2, pp. 128–136, 2021. [Online]. Available: https://doi.org/10.20344/amp.14574
[12] M. C. Grant, L. Geoghegan, M. Arbyn, Z. Mohammed, L. McGuinness, E. L. Clarke, and R. G. Wade, “The prevalence of symptoms in 24,410 adults infected by the novel coronavirus (SARS-CoV-2; COVID-19): A systematic review and meta-analysis of 148 studies from 9 countries,” PLoS One, vol. 15, no. 6, p. e0234765, 2020. [Online]. Available: https://doi.org/10.1371/journal.pone.0234765
[13] E. A. S. Medeiros, “A luta dos profissionais de sade no enfrentamento da COVID-19,” Acta Paul Enferm., p. 33, 2020. [Online]. Available: http://dx.doi.org/10.37689/acta-ape/2020EDT0003
[14] Secretaria de Vigiláncia em Saúde. (2021) Recomendações de proteção aos trabalhadores do serviço de saúde no contexto da pandemia da Covid-19. Ministério da Saúde, Brasil. [Online]. Available: https://bit.ly/3pvZ3lX
[15] C. D. Cappa, S. B. Sima Asadi, A. S. Wexler, N. M. Bouvier, and W. D. Ristenpart, “Expiratory aerosol particle escape from surgical masks due to imperfect sealing,” Scientific Reports, no. 11, p. 12110, 2021. [Online]. Available: https://doi.org/10.1038/s41598-021-91487-7
[16] ANVISA, Nota Técnica GVIMS/GGTES/ANVISA N? 04/2020. Orientações para serviços de saúde: medidas de prevenção e controle que devem ser adotadas durante a assistencia aos casos suspeitos ou confirmados de infecção pelo novo coronavirus (SARS-CoV-2). Agéncia Nacional de Vigiláncia Sanitária, 2021. [Online]. Available: https://bit.ly/3z12T9X
[17] ABNT, Equipamento de proteção respiratória – Filtros para partículas. Associação Brasileira de Normas Técnicas (ABNT), 2010. [Online]. Available: https://bit.ly/3qwTiUF
[18] ——, Equipamento de proteção respiratória – Peça semifacial filtrante para partículas. Associação Brasileira de Normas Técnicas (ABNT). [Online]. Available: https://bit.ly/3qqm09z
[19] IBSP. (2020) Máscaras n95 – recomenda˜ccões para uso prolongado e reutiliza˜ccão. Instituto Brasileiro Para Segurança Do Paciente. [Online]. Available: https://bit.ly/3Jpfd8D
[20] S. Duncan, P. Bodurtha, and S. Naqvi, “The protective performance of reusable cloth face masks, disposable procedure masks, kn95 masks and n95 respirators: Filtration and total inward leakage,” PLoS One, vol. 16, no. 10, p. e0258191, 2021. [Online]. Available: https://doi.org/10.1371/journal.pone.0258191
[21] C. C. Ontiveros, D. C. Shoults, S. MacIsaac, K. D. Rauch, C. L. Sweeney, A. K. Stoddart, and G. A. Gagnon, “Specificity of UV-C LED disinfection efficacy for three N95 respirators,” Scientific Reports, no. 11, p. 15350, 2021. [Online]. Available: https://doi.org/10.1038/s41598-021-94810-4
[22] D. B. Larremore, B. Wilder, E. Lester, S. Shehata, J. M. Burke, J. A. Hay, T. Milind, M. J. Mina, and R. Parker, “Test sensitivity is secondary to frequency and turnaround time for covid-19 surveillance,” medRxiv : the preprint server for health sciences, vol. 20, p. 20136309, Sep 2020. [Online]. Available: https://dx.doi.org/10.1101/2020.06.22.20136309
[23] CDC. (2020) Research Use Only 2019-Novel Coronavirus (2019-nCoV) Real-time RT-PCR Primers and Probes. Centers for Disease Control and Prevention. [Online]. Available: https://bit.ly/3EBvJyF
[24] T. I. C. on Non-Ionizing Radiation Protection, “Guidelines on limits of exposure to ultraviolet radiation of wavelengths between 180 nm and 400 nm (incoherent optical radiation),” Health Physics, vol. 87, no. 2, 2004. [Online]. Available: https://doi.org/10.1097/00004032-200408000-00006
[25] M. E. R. Darnell, K. Subbarao, S. M. Feinstone, and D. R. Taylor, “Inactivation of the coronavirus that induces severe acute respiratory syndrome, SARS-CoV,” J Virol Methods, vol. 121, no. 1, pp. 85–91, Oct. 2004. [Online]. Available: https://doi.org/10.1016/j.jviromet.2004.06.006
[26] K. Bedell, A. H. Buchaklian, and S. Perlman, “Efficacy of an automated multiple emitter whole-room ultraviolet-c disinfection system against coronaviruses mhv and mers-cov,” Infection Control & Hospital Epidemiology, vol. 37, no. 5, pp. 598–599, 2016. [Online]. Available: https://doi.org/10.1017/ice.2015.348
[27] F. A. Alexandre, J. A. F. Faria, and C. F. Cardoso, “Avaliação da eficiéncia da radiação ultravioleta na esterilização de embalagens plásticas,” Ciéncia e Agrotecnologia, vol. 32, no. 5, pp. 1524–1530, 2008. [Online]. Available: https://bit.ly/3mAbDie
[28] J. S. Smith, H. Hanseler, J. Welle, R. Rattray, M. Campbell, T. Brotherton, T. Moudgil, T. F. Pack, K. Wegmann, S. Jensen, J. Jin, C. B. Bifulco, S. A. Prahl, B. A. Fox, and N. L. Stucky, “Effect of various decontamination procedures on disposable n95 mask integrity and sars-cov-2 infectivity,” Journal of clinical and translational science, vol. 5, no. 1, pp. e10–e10, Jun 2020. [Online]. Available: https://dx.doi.org/10.1017/cts.2020.494
[29] M. Biasin, A. Bianco, G. Pareschi, A. Cavalleri, C. Cavatorta, C. Fenizia, P. Galli, L. Lessio, M. Lualdi, E. Tombetti, A. Ambrosi, E. M. A. Redaelli, I. Saulle, D. Trabattoni, A. Zanutta, and M. Clerici, “Uv-c irradiation is highly effective in inactivating sars-cov-2 replication,” Scientific Reports, vol. 11, no. 1, p. 6260, Mar 2021. [Online]. Available: https://doi.org/10.1038/s41598-021-85425-w
[30] CDC. Implementing Filtering Facepiece Respirator (FFR) Reuse, Including Reuse after Decontamination, When There Are Known Shortages of N95 Respirators. Centers for Disease Control and Prevention. [Online]. Available: https://bit.ly/3sD9ypQ
[31] K. O’Hearn, S. Gertsman, M. Sampson, R. Webster, A. Tsampalieros, R. Ng, J. Gibson, A. T. Lobos, N. Acharya, A. Agarwal, S. Boggs, G. Chamberlain, E. Staykov, L. Sikora, and J. D. McNally, “Decontaminating n95 and sn95 masks with ultraviolet germicidal irradiation does not impair mask efficacy and safety,” vol. 106, no. 1, pp. 163–175. [Online]. Available: https://doi.org/10.1016/j.jhin.2020.07.014
[32] L. Liao, W. Xiao, M. Zhao, X. Yu, H. Wang, Q. Wang, S. Chu, and Y. Cui, “Can n95 respirators be reused after disinfection? how many times?” ACS nano, vol. 14, no. 5, pp. 6348–6356, May 2020. [Online]. Available: https://dx.doi.org/10.1021/acsnano.0c03597
[33] W. G. Lindsley, S. B. Martin, Jr, R. E. Thewlis, K. Sarkisian, J. O. Nwoko, K. R. Mead, and J. D. Noti, “Effects of ultraviolet germicidal irradiation (UVGI) on N95 respirator filtration performance and structural integrity,” J Occup Environ Hyg, vol. 12, no. 8, pp. 509–517, 2015. [Online]. Available: https://doi.org/10.1080/15459624.2015.1018518
[34] ABMT. 87 % das denúncias de falta de EPIs são sobre máscaras N95, diz AMB. Associação Brasileira de Medicina do Trabalho. [Online]. Available: https://bit.ly/3JlBFj5
[35] J. Rose. (2020) Why can’t america make enough n95 masks? 6 months into pandemic, shortages persist. NPR. SPECIAL SERIES The Coronavirus Crisis. [Online]. Available: https://n.pr/3mBjImT
[36] K. Seresirikachorn, V. Phoophiboon, T. Chobarporn, K. Tiankanon, S. Aeumjaturapat, S. Chusakul, and K. Snidvongs, “Decontamination and reuse of surgical masks and N95 filtering facepiece respirators during the COVID-19 pandemic: A systematic review,” Infect Control Hosp Epidemiol, vol. 42, no. 1, pp. 25–30, Jul. 2020. [Online]. Available: https://doi.org/10.1017/ice.2020.379
[37] E. C. Toomey, Y. Conway, C. Burton, S. Smith, M. Smalle, X.-H. S. Chan, A. Adisesh, S. Tanveer, L. Ross, I. Thomson, D. Devane, and T. Greenhalgh, “Extended use or reuse of single-use surgical masks and filtering face-piece respirators during the coronavirus disease 2019 (COVID-19) pandemic: A rapid systematic review,” Infect Control Hosp Epidemiol, vol. 42, no. 1, pp. 75–83, Oct. 2020. [Online]. Available: https://doi.org/10.1017/ice.2020.1243
[38] NEVMS, Descontaminação de máscaras de proteção respiratória modelo N95 (respirador particulado). Núcleo de Evidéncia de Mato Grosso do Sul, 2020. [Online]. Available: https://bit.ly/345EmW1
[39] B. K. Heimbuch, W. H. Wallace, K. Kinney, A. E. Lumley, C.-Y. Wu, M.-H. Woo, and J. Wander, “A pandemic influenza preparedness study: use of energetic methods to decontaminate filtering facepiece respirators contaminated with H1N1 aerosols and droplets,” Am J Infect Control, vol. 39, no. 1, pp. e1–9, Dec. 2010. [Online]. Available: https://doi.org/10.1016/j.ajic.2010.07.004
[40] S. Sangkham, “Face mask and medical waste disposal during the novel covid-19 pandemic in asia,” vol. 2, p. 100052. [Online]. Available: https://doi.org/10.1016/j.cscee.2020.100052